diff --git a/Misc/NEWS.d/next/Library/2022-05-05-19-25-09.gh-issue-92356.uvxWdu.rst b/Misc/NEWS.d/next/Library/2022-05-05-19-25-09.gh-issue-92356.uvxWdu.rst
new file mode 100644
index 0000000000000000000000000000000000000000..9c9566e5b9d7197e03e816a7b484c8488a9088ab
--- /dev/null
+++ b/Misc/NEWS.d/next/Library/2022-05-05-19-25-09.gh-issue-92356.uvxWdu.rst
@@ -0,0 +1 @@
+Fixed a performance regression in ctypes function calls.
diff --git a/Modules/_ctypes/cfield.c b/Modules/_ctypes/cfield.c
index 23c11c98b2afce0225f53281a9dd7ff028382a91..c7234fbb18a0fa8e60ae6a717e5e292382903795 100644
--- a/Modules/_ctypes/cfield.c
+++ b/Modules/_ctypes/cfield.c
@@ -1602,6 +1602,7 @@ _ctypes_get_fielddesc(const char *fmt)
     struct fielddesc *table = formattable;
 
     if (!initialized) {
+        initialized = 1;
         _ctypes_init_fielddesc();
     }